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Location: Wiltshire UK
Joined: Nov 2010
Posts: 14,404
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Originally Posted by
Nightwolf
Seasonal Alopesha? What causes that, I am guessing its something seasonal? lol. So is this a bad thing? Or did something bad cause it?
We thought it was due to her rolling round the field, maybe picked something up?
Seasonal flank alopecia S
easonal flank alopecia (Canine Recurrent Flank Alopecia - CRFA) is a cyclical or episodic follicular disease that occurs when daylight begins to shorten (fall of the year) with progression through the winter. A typical history describes the development of patchy alopecia and hyper-pigmentation on the lateral thorax and flanks that can be unilateral or bilateral. Lesions may ultimately involve the entire lateral thorax, abdomen and rump regions. Margins of the affected areas are "geographic" in appearance with sharply demarcated borders. Spontaneous regrowth of hair may occur as the hours of daylight lengthen (spring). With each season the pattern of hair loss returns, may be more prolonged than the last and the dog may fail to completely regrow hair before the next episode. Seasonal flank alopecia has been reported in numerous breeds but is recognized most frequently in Boxers, English Bulldogs, Airedales, Schnauzers, Doberman Pinschers and Bouvier des Flanders. Although age of onset is typically between 3-5 years, the condition can occur at any age. There is no sex predilection.
Causes and pathogenesisThe cause of CRFA is unknown. The seasonal and reoccurring pattern along with response to melatonin supplementation suggest that photoperiod and melatonin play a role. This theory is supported by the fact that in Southern Hemisphere countries like Australia and New Zealand, where seasons are the reverse of that in the Northern Hemisphere, the onset of CRFA occurs the reverse of what is seen in the Northern Hemisphere but corresponds to seasonal changes in light: dark periods.
Melatonin, a hormone synthesized in the pineal gland, is involved in neuroendocrine control of photoperiod-dependent molting and hair growth in many mammals, but the mechanism by which this occurs is not clear. There is a synergistic effect of prolactin, another photo dependent hormone, and melatonin. Regulation of seasonal shedding is thought to be one important effect of these hormones at the level of the hair follicle. Melatonin secretion occurs as an inverse function of day length and is produced primarily at night. When days are longer (spring/summer), melatonin concentrations go down and prolactin goes up initiating the spring molt with growth of a summer coat. As days get shorter the opposite occurs initiating growth of a winter coat. In dogs with seasonal flank alopecia this cycle is believed to be disordered.
Diagnosis and treatmentHistory, breed, clinical signs and elimination of endocrine causes of symmetrical alopecia (hypothyroidism, hyperadrenocorticism) place CRFA high on the differential diagnoses list. Skin biopsies show an atrophic and dysplastic follicular pattern with follicular hyperkeratosis that takes on the appearance of "witches feet".
Treatment options are limited. Response to melatonin supplementation orally or via subcutaneous implants seems to be beneficial, although the cyclical nature of the disease can make it difficult to prove. Controlled studies have not been done to provide the necessary support for this treatment. The dose is empirical (6-12 mg 8-12h PO) and response variable. Melatonin is unlikely to affect a cure but may reduce the severity of lesions that develop or at least reduce the course of the clinical cycle. Since melatonin has been shown to regulate reproductive events in some animals, it should not be used in breeding animals.
Light therapy (regulating the amount of artificial light) has been reported to be helpful in some dogs. The dog is exposed to 15-16 hours of "daylight" via a 100-200 watt incandescent bulb. Light therapy that starts in September and continues through the spring may prevent the condition. Of course benign neglect (no treatment) is also a viable option in these otherwise healthy dogs.