she has got a bed she will go to, when all her crying and pleading fails and its definately me that needs to toughen up, i don`t want her stressed everytime we have to leave her.

Also it might be worth looking into something like a DAP spray, plug-in or collar (Beaphar do a collar at a better price too), these are pheromone based so calm the dog down. They don't work with every dog but may help.

never heard of them, it cant be a collar as she is far too tiny to get 1 to fit, but could try the plug-in, where would i find one of those?

are they safe for such a young puppy? or do i need to wait until shes a little older?

DAP make a puppy and small breed collar and I believe the design means they can go as small as you need so one might fit.
http://www.dap-pheromone.com
Their website mentions using the collar from 6 weeks old to allow puppies to settle. It also has a bit saying
"Staying Home Alone

Spending time alone can be challenging for a puppy unused to solitude. Excessive vocalization and attention seeking behaviours are common.

Using DAP® to reduce early signs of separation problems or to help young dogs cope with staying home alone

• A DAP® Diffuser should be plugged in, preferably at floor level next to where the dog is going to sleep and spend time while alone.

• The diffuser should be switched on continuously for at least 4 weeks.

If a dog is showing sings of a stress-related problem, the dog should be referred to a qualified behavioural therapist. Puppies are unlikely to grow out of a behaviour problem. "

thankyou for the advice its really useful, i will take a look at the site, and keep everyone informed of Mouse`s progress x

Try leaving a radio on so that she thinks there are still people in the house, Radio 4 is good for that. Also try leaving an old t-shirt or pair of socks in her bed so that she has the smell of you around while you're out.