Also please quit straight up lying about lifespans, most giant breeds are around 8 to 10 years. The only one which comes in at your 5-7 years off the top of my head is the
Dogue de Bordeaux at 5 to 8. Please join a giant breed forum and ask how important health testing is.

Many giant breeds actually live to be 11 to 14 years with the proper diet, care, and exercise.

Also the DNA testing I'm speaking of has zero to do with paternity.
I've had several to live past 10 years.

Has anyone stated as a fact that all BYB and puppy mills breed unhealthy dogs?

When I bred Griffons I did not have kennels, my dogs lived in my house, and I was a Kennel Club [UK] registered breeder. The puppies I bred were 100% healthy, but because they were bred in my house with my family, did that make me a BYB?

Actually many breeders of "pedigree" dogs are BYBs or puppy mills. Anyone can get hold of "official" Pedigree forms and fill them out as they want. When I was an active breeder it was - and possibly still is - easy to telephone any dog food manufacturer and ask if they could please send you some fancy Pedigree forms.

And not all registered pedigree dogs are what they are registered as - because unless the person registering the puppies is 100% honest regarding the dam and the sire, how can any Kennel Club be 100% sure that they are those as actually those registered?

It was a well-known but unspoken [in those days] fact that on occasions a Griffon breeder would use a Pug as a stud and yet register the puppies under the name of a Griffon stud.

"Statistical sampling" is just that. Random statistic sampling which actually means nothing apart from the samples studied.

Nothing more than hypothesis - because X number of dogs/cats/humans show this/that/whatever disease does not make it a fact.

An hypothesis is not a fact.

And "statistic sampling" proves nothing. It is like standing in a shopping centre with a clipboard and asking passers-by if they have ever heard of/suffered from/used such-and-such a product.

Health Screening
Before dogs are approved and used for breeding, they should undergo an extensive health screening process. This would of course allow any competent veterinarian to discover any kind of clearly apparent illness or deformity, but a health screening in this case needs to look well beyond the obvious. Different breeds of dog are vulnerable to different kinds of serious disorders and disease, and a thorough pre-breeding health screening should be performed to detect any genetic conditions or malformations that would disqualify a dog from being used for the purposes of breeding.

Some of the tests that should be performed to detect hereditary disorders and abnormalities include:
• Hip Scoring – many breeds of dog can be vulnerable to a condition called hip dysplasia. This is an abnormal formation of the hip socket that is both physically debilitating and very painful. Before being allowed to breed, all dogs should go through the hip scoring procedure, which involves a physical examination of their hip sockets taken by radiograph. Each dog so tested is then given a score based on the formation of their hip sockets, with a lower score being the best. Only those dogs that score well below average should be considered suitable for breeding.
• Cardiac testing – dogs can suffer from congenital heart disease, which can lead to illness and a slow, painful death. Each type of dog has a somewhat different testing protocol, which is determined by clubs devoted to that breed. But the basic procedure involves the monitoring and examination of the heart by electrocardiogram and echocardiogram, in the search for irregularities that might demonstrate the presence of hereditary abnormalities.
• Eye testing – dogs can be subject to a number of genetic eye conditions, ranging from minor to capable of causing blindness. At least 11 different tests exist for different conditions, and puppies can usually be tested at a fairly young age with accurate results.
• Syringomyelia – sometimes called the neck-scratching disease; but unfortunately the neck scratching exhibited by dogs in this case is only a side effect of a condition of the spinal cord that can degenerate into paralysis. There is a good test for this disorder, but because it can manifest later on a dog should not be tested until the age of two and a half.

The important thing to realize is that dogs that suffer from these disorders and abnormalities do, in fact, suffer greatly, and it is incumbent on breeders to try and eliminate these conditions from the breeding stock if it is at all possible.

A good breeder does those things.
If he is a show or a working dog breeder.

I don't need a study published online, to show me how true it is after the amount of time I have owned Mastiffs.

It easy enough. If you google breeders and look at the dogs from those that do not health test and sell cheap to those that do test and do proper birth, and raising.