Sorry but this will be long.
GERMAN SHEPHERD DOG
Alopecia : Congenital focal alopecia areata with areas of dark pigmentation.
Aortic stenosis: Fibrous ring develops below aortic valve. Signs and heart murmur may progress or remain static.
Calcinosis circumscripta : A disease in which there is deposition of calcium salts in soft tissues as aggregates of amorphous/granular material.
Cataract : Defective eyesight due to opacity of lens.
Cauda equina syndrome : Low-back pain, saddle anesthesia, bilateral sciatica, then motor weakness of the lower extremities or chronic paraplegia and, bladder dysfunction.
Cutaneous vasculopathy : Footpad swelling/depigmentation: necrosis of basal cells in depigmented lesions, nodular dermatitis; pyrexia, lethargy, ulceration of extremities.
Degenerative myelopathy : Slow progressive posterior paresis from 5 years of age. Diffuse myelopathy of spinal cord.
Dilated cardiomyopathy : Ventricular arrhythmias of suspected right ventricular (RV) origin, syncope, and heart failure. Cardiomyopathy with fatty degeneration.
Ectodermal dysplasia : Symmetrical areas of hairlessness; missing and misshapen teeth. No hair follicles, adnexal structures, or eccrine glands in affected areas.
Elbow dysplasia : Swollen painful elbows and lameness. Osteochondritis dissecans (OCD), United anconeal process, Ununited (or fragmented) coronoid process.
Epilepsy : Intermittent seizures, not always hereditary can be caused by brain injury, there are known lines which carry this.
Exocrine pancreatic insufficiency : Chronic inadequate digestion: voluminous foul smelling faeces. Inflammation of pancreas.
Gastric dilatation/ volvulus : Gastric displacement and delayed gastric emptying lead to vomiting, distended and painful abdomen, shock.
Giant Axonal Neuropathy : Posterior paresis and ataxia by 15 months. Large axonal swellings, neurofilaments in CNS and PNS.
Haemophilia A : X-linked blood clotting disorder
Haemophilia B : X-linked blood clotting disorder.
Hereditary ventricular tachycardia : Ventricular arrhythmias (premature ventricular contraction, ventricular tachycardia) esp. during REM sleep and sudden death.
Hip dysplasia : Lameness in hind legs and gait problems.
Hyperparathyroidism and renal cortical hypoplasia (juvenile) : Stunted growth, muscular weakness, and polydipsia/polyuria.
IgA deficiency - inflammatory enteropathy : Small intestinal disease of adult onset: chronic diarrhoea. Low serum IgA
Laryngeal paralysis : Exercise intolerance, respiratory problems, gagging, coughing and loss of voice.
Masticatory muscle myositis : Immune mediated muscle disease causes severe jaw muscular atrophy, preventing jaw opening more than a centimetres.
Mitral (left atrio-ventricular) valve defects : Left atrio-ventricular valve defects and heart murmur in adults.
Mucopolysaccharidosis VII (Sly syndrome) : Beta-glucuronidase deficiency: weakness and neurological and skeletal signs from 8 weeks.
Neoplasia - haemangioma & haemangiosarcoma : Excess of haemangioma and haemangio sarcoma.
Pannus : Inflammation of the surface of the eye.
Panosteitis : Inflammatory bone disease causing lameness in rapidly growing dogs of 6-18 months. The disease appears to be aggravated by excessive physical activity.
Patent ductus arteriosus ; Blood shunting of variable severity depending on extent of vessel patency.
Persistent right aortic arch : Aortic arch abnormally producing an encircling ring around trachea and oesophagus.clinical sigs of regurgitation, aspiration pneumonia and failure to thrive due to oesophageal compression.
Pituitary dwarfism (combined pituitary hormone deficiency) : Dwarfism. Depressed or zero circulating growth hormone and IGF-1.
Platelet mediated bleeding disorder : Clotting disorder. Washed platelets show twice normal clotting times
Progressive Retinal Atrophy : Loss of night vision progressing slowly to total blindness.
Pyoderma (skin infections) : Recurrent deep skin infections especially of rear and lower flanks
Renal cystadenocarcinoma and nodular dermatofibrosis : Firm collagenous nodules in the skin and subcutis with bilateral multifocal tumors in kidneys
Spinal muscular atrophy : Progressive generalised weakness and forelimb deformities.
Subaortic stenosis : Fibrous ring develops below aortic valve
Systemic lupus erythematosis : Febrile polyarthritis, wasting, signs of renal disease, cutaneous lesions
Tricuspid (right atrio-ventricular) valve dysplasia : Thickened tricuspid valve leaflets with fenestrations and attached papilliary muscles, regurgitant blood flow.
Type 1 von Willebrand disease : Blood clotting disorder.
Ventricular arrythmias : Abnormalities in heart beat.
The only tests the KC recommend are Hip scoring, elbow scoring, eye testing.
Current research;
Renal Dysplasia contact Videx GSD
Haemangiosarcoma Cambridge Veterinary Dept, Cambridge University have your vet contact Dr David Sargon for form to submit bloods for dogs being treated with this.
Dwarfism (Hypothpituitarism) http://www.accdata.co.uk/dwarfism
Haemolytic anaemia, Hypothyroidism, Addison's disease; Thrombocytopenia; SLE; Polyarthritis; Pemphigus; EPI and other auto immune diseases get your vet to contact
jo@cimda.fsnet.co.uk
the Breed Council collect health related data to include on their database contact John Allinson
Urine samples from dogs suffering from DM get your vet to contact Dr Brian Catchpole at the Royal Vet college
Haemophilia A all males should be blood tested contact Animal Health Trust
Atopic Dermatitis (Atopy) get vet to contact University of Glasgow Veterinary School or AHT.
OCD/HD/ED If you have an animal suffering from any of these conditions further details of the research can be obtained by your vet contacting Royal Veterinary College or University of Liverpool
Elbow Dysplasia, Hip Dysplasia, Cruciate Disease, Inflammatory Polyarthritis, Anal Furunculosis, Lymphoma, EPI, Hypoadrenocorticism, Diabetes Mellitus, Atopic Dermatitis, Obesity, Gastric Dilatation, Hypothyroidism, Mast Cell Tumours, Soft Tissue Sarcomas, Gastric Carcinoma, Pyoderma, Cataracts, Melanoma, Otitis, Haemangiosarcoma, Lymphosarcoma, Pancreatitis, Patellar Luxation, Syringomyelia, Mitral Valve Disease, Canine Epilepsy. ; FURTHER INFO: If you are a veterinary practitioner or researcher who is in a position to contribute blood samples from animals suffering from one of these diseases and/or healthy controls, or you represent a breed club with an interest in helping to collect samples, please contact Wendy Hallows at
Whallows@liverpool.ac.uk to obtain the relevant criteria sheet.